Sinequan is very sedating
Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech).
Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.
This is followed by CNS depressant effects, including hypothermia, decreased or absent reflexes, sedation, hypotension, cyanosis, and cardiac irregularities, including tachycardia, conduction disturbances, and quinidine-like effects on the ECG.
Severity of overdose is best indicated by widening of QRS complex.
The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission.
The first 12 hours after acute ingestion are a stimulatory phase characterized by excessive anticholinergic activity (agitation, irritation, confusion, hallucinations, hyperthermia, parkinsonian symptoms, seizures, urine retention, dry mucous membranes, pupillary dilatation, constipation, and ileus).
Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders.
These medications can help prevent suicidal thoughts/attempts and provide other important benefits.
In depressed individuals, doxepin exerts a positive effect on mood.
TCAs are potent inhibitors of serotonin and norepinephrine reuptake.